Novel needs are raising in an ever-changing world rendering C. elegans-based toxicity screening essential for several industries.

In cosmetics, societal pressure ended to the ban of animal-tested cosmetic ingredients in Europe in 2013 (EC Regulation 1223/2009 on cosmetics) or at least to Reduction, Refinement and Replacement (the 3Rs) of animal testing.  Alternative methods such as cell-based assays will not provide as accurate results regarding genotoxicity, reprotoxicity, systemic toxicity.  This is where CeleScreen can help the cosmetics industry to effectively assess the toxicity of novel ingredients for, e.g., anti-ageing, skin whitening.

In medical research and in the exploratory phases of drug development, every day, practitioners push the limits of whatever methods, in vivo, in cellulo, in vitro, in silico.  CeleScreen will offer to leverage the well-known C. elegans model and its more than 8,000 transgenic strains (Caenorhabditis Genetics Center of the University of Minnesota), in standardized, whole-organism, toxicity or activity assays in physiological conditions. Combining C. elegans with in silico modeling and prediction of ADME-T parameters, CeleScreen proposes to pharmaceutical industry, the possibility in one shot, to optimize lead compounds, by selecting the best ones with the ideal PKPD properties, the best activity and the optimal safety, while validating their pharmacological targets.

Also in occupational health, where endocrine disruptors have raised as a major concern, CeleScreen will help untangle U-shaped dose response curves, synergistic effects, and other complexity sources, in a portable, field, systemic method.